おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
化学種の反応性
human
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 9-14 μg/mL
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CXCR4(7852)
mouse ... Cxcr4(12767)
rat ... Cxcr4(60628)
免疫原
ヒトCXCケモカインレセプタ-4(CXCR4)の細胞質第三ル-プに相当する合成ペプチドのKLH結合体。免疫ペプチドはラット、マウス遺伝子と100%のホモロジ-を有しています。
アプリケーション
Anti-CXCR4 antibody produced in rabbit is suitable for immunohistochemistry of formalin-fixed, paraffin-embedded tissue sections at a working concentration of 9-14 μg/mL. It was used to stain rat bladder sections at a dilution of 1:2000, incubated overnight.
生物化学的／生理学的作用
CXCR4 is a cell surface receptor of the chemokine CXCL12 (SDF-1) and is involved in metastasis, hematopoiesis and immune responses. It acts with CD4 to facilitate the entry of HIV into target cells. CXCR4 has important roles in tumor initiation, proliferation, invasion and metastasis of breast cancer cells.
物理的形状
Solution in phosphate buffered saline, containing 0.1% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C3116-50UL:
C3116-50UL-PW:
C3116-BULK:
C3116-VAR:
M J Walters et al.
British journal of cancer, 110(5), 1179-1188 (2014-01-16)
In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12, in the tumour's response to IR has not been addressed. We
Angelo Ferrari et al.
BMC veterinary research, 8, 27-27 (2012-03-16)
Mammary tumours frequently develop in female domestic cats being highly malignant in a large percentage of cases. Chemokines regulate many physiological and pathological processes including organogenesis, chemotaxis of inflammatory cells, as well as tumour progression and metastasization. In particular, the
Pedro L Vera et al.
PloS one, 3(12), e3898-e3898 (2008-12-11)
Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro. We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis. Twenty male
Max Yan et al.
Breast cancer research : BCR, 13(2), R47-R47 (2011-04-28)
Basal-like breast cancers behave more aggressively despite the presence of a dense lymphoid infiltrate. We hypothesised that immune suppression in this subtype may be due to T regulatory cells (Treg) recruitment driven by hypoxia-induced up-regulation of CXCR4 in Treg. Immunoperoxidase
Bikash Debnath et al.
Theranostics, 3(1), 47-75 (2013-02-06)
CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV, cancer, WHIM syndrome, rheumatoid arthritis, pulmonary fibrosis and lupus. For
資料
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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