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Key Documents

安全性情報

C1743

Sigma-Aldrich

モノクロナール抗Cul7

clone Ab38, purified from hybridoma cell culture

別名:

Anti-Cullin 7, Anti-KIAA007

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About This Item

MDL番号:
UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

mouse

品質水準

結合体

unconjugated

抗体製品の状態

purified immunoglobulin

抗体製品タイプ

primary antibodies

クローン

Ab38, monoclonal

形状

buffered aqueous solution

分子量

antigen ~180 kDa

化学種の反応性

human, mouse

濃度

~2 mg/mL

テクニック

immunoprecipitation (IP): suitable
western blot: 0.5-1 μg/mL using 3T3 total cel extract

アイソタイプ

IgG2b

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... CUL7(9820)
mouse ... Cul7(66515)

詳細

Monoclonal Anti-Cul7 (mouse IgG2b isotype) is derived from the hybridoma Ab38 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from BALB/c mice immunized with mouse Cul7. CUL7 is expressed in all tissues and cell lines except testis and small intestine.

免疫原

mouse Cul7.

アプリケーション

Monoclonal Anti-Cul7 antibody produced in mouse is suitable for immunoprecipitation and western blotting at a concentration of 0.5-1μg/mL using 3T3 total cel extract.

生物化学的/生理学的作用

CUL7 functions to promote cell growth through and antagonizes the function of p53.
Cullin-7 (cul7) is a protein encoded by the CUL7 gene in humans. It is also referred as 3M1, KIAA0076 and dJ20C7.5. Mutation in CUL7 gene is majorly responsible for 3M syndrome (is a rare autosomal recessive disorder). CUL7 acts as a novel gene potentially involved in liver carcinogenesis associated with metabolic syndrome (MS) and its amplification may influence cell proliferation.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

C1743-VAR:
C1743-200UL:
C1743-25UL:
C1743-BULK:
C1743-100UL:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Cristina Meazza et al.
Italian journal of pediatrics, 39, 21-21 (2013-03-23)
3-M syndrome is a rare autosomal recessive disorder that causes short stature, unusual facial features and skeletal abnormalities. Mutations in the CUL7, OBSL1 and CCDC8 genes could be responsible for 3-M syndrome.Here we describe the growth and evolution of dismorphic
Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function
Andrews P, et al.
Oncogene, 25(33), 4534-4534 (2006)
Céline Huber et al.
Best practice & research. Clinical endocrinology & metabolism, 25(1), 143-151 (2011-03-15)
3M syndrome (MIM 273750) is an autosomal recessive disorder characterized by pre- and post-natal growth retardation (<-4 SD), facial dysmorphism, large head circumference, normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. There
Céline Huber et al.
European journal of human genetics : EJHG, 17(3), 395-400 (2009-02-20)
The 3M syndrome is a rare autosomal recessive disorder recently ascribed to mutations in the CUL7 gene and characterized by severe pre- and postnatal growth retardation. Studying a series of 33 novel cases of 3M syndrome, we have identified deleterious
Valerie Paradis et al.
Gut, 62(6), 911-919 (2012-09-04)
Metabolic syndrome (MS) is an emerging risk factor in hepatocellular carcinoma (HCC). HCC related to MS may occur either in advanced fibrosis or before the development of cirrhosis, suggesting involvement of different molecular pathways according to the features of background

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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