B6309

(R)-ブタプロスト

≥98% (HPLC)

• 別名: (1R,2R,3R)-3-ヒドロキシ-2-[(1E,4R)-4-ヒドロキシ-4-(1-プロピルシクロブチル)-1-ブテニル]-5-オキソ-シクロペンタンヘプタン酸メチルエステル
• 実験式（ヒル表記法）: C₂₄H₄₀O₅
• CAS番号: 69648-38-0
• 分子量: 408.57
• MDL番号: MFCD00867055
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724423
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: oil
• 色: light yellow
• 溶解性: DMSO: freely soluble; ethanol: freely soluble
• オーガナイザー: Bayer
• 保管温度: −20°C
• SMILES記法: CCCC1(CCC1)[C@H](O)C\C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC
• InChI: 1S/C24H40O5/c1-3-14-24(15-9-16-24)22(27)12-8-11-19-18(20(25)17-21(19)26)10-6-4-5-7-13-23(28)29-2/h8,11,18-19,21-22,26-27H,3-7,9-10,12-17H2,1-2H3/b11-8+/t18-,19-,21-,22-/m1/s1
• InChI Key: XRISENIKJUKIHD-LHQZMKCDSA-N

詳細

アプリケーション

(R)-Butaprost has been used as a prostanoid receptor (EP)-specific agonist to study its effects on protein kinase A (PKA) regulatory subunits in MCF7 cells. It may be used as EP2 agonist in Madin-Darby canine kidney and mouse cortical collecting duct (mpkCCD14) cells. It may also be used as EP2 agonist in human fetal lung fibroblasts (HFL-1) cells to test its effect on vascular endothelial growth factor (VEGF) production.

生物化学的／生理学的作用

Butaprost comprises hydroxy-cyclopentanone ring and ω-chain. It aids protection in events of glutamate based N-methyl-D-aspartate receptor toxicity. Butaprost inhibits conjunctival fibrosis and lowers the intraocular pressure in post glaucoma filtration surgery. It also promotes wound healing by reducing the subconjunctival scarring Tenon′s fibroblasts. Butaprost plays a protective role in pulmonary fibrosis and aids protection against the aggregated amyloid β (Aβ) peptides in Alzheimer′s disease.

(R)-ブタプロストは、EP₂プロスタノイドレセプタ-の選択的なアゴニストです。

特徴および利点

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)