おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
分子量
48 kDa
交差性
human
濃度
0.5 mg - 1 mg/mL
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... KCNN4(3783)
関連するカテゴリー
詳細
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, KCNN4, is a component of a potassium channel activated by calcium. It is critically involved in calcium ion transport and cell homeostasis.
免疫原
Synthetic peptide directed towards the C terminal region of human KCNN4
アプリケーション
Anti-KCNN4 antibody produced in rabbit has been used in:
- western blot analysis
- immunofluorescence
- staining
- immunohistochemistry
生物化学的／生理学的作用
KCNN4 (potassium calcium-activated channel subfamily N member 4) is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. KCNN4 may be part of the predominant calcium-activated potassium channel in T-lymphocytes. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
シーケンス
Synthetic peptide located within the following region: DLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
物理的形状
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AV35098-50UG:
AV35098-100UL:
最新バージョンのいずれかを選択してください：
Epigenetic dysregulation of KCa3. 1 channels induces poor prognosis in lung cancer
Bulk E, et al.
International Journal of Cancer. Journal International Du Cancer, 137(6), 1306-1317 (2015)
A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes
Logsdon NJ, et al.
The Journal of Biological Chemistry, 272(52), 32723-32726 (1997)
Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3. 1 and ClC-3
Cuddapah VA, et al.
The Journal of Neuroscience, 33(4), 1427-1440 (2013)
D Strøbæk et al.
British journal of pharmacology, 168(2), 432-444 (2012-08-16)
The K(Ca) 3.1 channel is a potential target for therapy of immune disease. We identified a compound from a new chemical class of K(Ca) 3.1 inhibitors and assessed in vitro and in vivo inhibition of immune responses. We characterized the
Yi-Je Chen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 36(12), 2146-2161 (2015-12-15)
Activated microglia/macrophages significantly contribute to the secondary inflammatory damage in ischemic stroke. Cultured neonatal microglia express the K
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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