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Key Documents

AMAB91067

Sigma-Aldrich

Monoclonal Anti-MOG antibody produced in mouse

Prestige Antibodies® Powered by Atlas Antibodies, clone CL2858, purified immunoglobulin, buffered aqueous glycerol solution

別名:

BTN6

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About This Item

UNSPSCコード:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

由来生物

mouse

品質水準

結合体

unconjugated

抗体製品の状態

purified immunoglobulin

抗体製品タイプ

primary antibodies

クローン

CL2858, monoclonal

製品種目

Prestige Antibodies® Powered by Atlas Antibodies

形状

buffered aqueous glycerol solution

化学種の反応性

rat, mouse, human

テクニック

immunoblotting: 1 μg/mL
immunohistochemistry: 1:2500- 1:5000

アイソタイプ

IgG1

免疫原配列

ALVGDEVELPCRISPGKNATGMEVGWYRPPFSRVVHLYRNGKDQDGDQAPEYRGRTELLKDAIGEGKVTLRIRNVRFSDEGGFTCFFRDHSYQEEAAMELKVEDPFYWVSPG

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... MOG(4340)

詳細

Myelin oligodendrocyte glycoprotein (MOG) is usually present at the extracellular surface of myelin sheaths and oligodendrocytes in the central nervous system. The human MOG gene is located 60 kilobases (kb) telomeric to HLA-F (major histocompatibility complex, class I, F) in a head-to-head orientation. This gene is mapped to human chromosome 6p22.1.

免疫原

myelin oligodendrocyte glycoprotein

アプリケーション

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

生物化学的/生理学的作用

Myelin oligodendrocyte glycoprotein (MOG) is highly required for maternal embryogenesis. It plays a crucial role in the perpetuation of MS (multiple sclerosis). In animals, MOG acts as a target autoantigen in demyelinating diseases like autoimmune encephalomyelitis (EAE).

特徴および利点

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

関連事項

Corresponding Antigen APREST84510

物理的形状

40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.

法的情報

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 1

引火点(°F)

Not applicable

引火点(℃)

Not applicable


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region.
Pham-Dinh D, et al.
Immunogenetics, 42(5), 386-391 (1995)
More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegans..
Graham PL, et al.
Developmental Genetics, 14(6), 471-484 (1993)
Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis.
Nakajima H, et al.
BMJ Open, 5(4), e007766-e007766 (2015)
Immune modulation by a tolerogenic myelin oligodendrocyte glycoprotein (MOG) 10?60 containing fusion protein in the marmoset experimental autoimmune encephalomyelitis model.
Kap YS, et al.
Clinical and Experimental Immunology, 180(1), 28-39 (2015)
The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia.
Roig B, et al.
Molecular Psychiatry, 12(9), 833-833 (2007)

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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