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由来生物
rabbit
品質水準
抗体製品の状態
Ig fraction of antiserum
クローン
monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
形状
buffered aqueous solution
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:60
輸送温度
wet ice
保管温度
2-8°C
視覚化
nuclear
詳細
High-mobility group AT-hook 2 (HMGA2) is a chromatin factor that regulates transcription and cellular differentiation during embryonic development. HMGA2 helps to regulate the cell cycle and plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. It also interacts with transcription factor E4F1, protein kinase NEK2, and the promoter of the nucleotide excision-repair gene ERCC1 to negatively modulate its activity. HMGA2 expression in adult tissues is often associated with benign and malignant tumor formation. HMGA2 is expressed in most conventional and intramuscular lipomas, 84 and 100%, respectively and can aid in differentiating between lipomas from dedifferentiated liposarcomas and distinguishing areas of tumor from normal adipose tissue. In mesenchymal tumors, HMGA2 is expressed in 88% of benign fibrous histiocytoma, 90% of nodular fasciitis, and 90% of vulvovaginal angiomyxoma. Increased expression of HMGA2 occurs in other human malignancies, including pancreatic, gastric, oral squamous cell, ovarian, and a subset of breast cancers. In thyroid carcinomas, upregulation of HMGA2 can distinguish between benign and malignant follicular neoplasias. Further, HMGA2 overexpression is often found in non-small cell lung cancer and could be used as a marker for lung carcinomas. The presence of HMGA2 in cancer is correlative with metastasis and poor prognosis.
品質
 IVD |  IVD |  IVD |  RUO |
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
その他情報
For a copy of the IFU and CofA contact IVDorder@ABCAM.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
AC-0369:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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