A8227

AH23848 ヘミカルシウム塩 水和物

≥90% (HPLC), powder

• 別名: (4Z)-7-[(rel-1S,2S,5R)-5-((1,1′-ビフェニル-4-イル)メトキシ)-2-(4-モルホリニル)-3-オキソシクロペンチル]- 4-ヘプテン酸 ヘミカルシウム塩 水和物
• 実験式（ヒル表記法）: C₂₉H₃₄NO₅ · 0.5 Ca
• CAS番号: 81496-19-7
• 分子量: 496.62
• MDL番号: MFCD05665139
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724400
• NACRES: NA.77

特性

• アッセイ: ≥90% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear; H₂O: insoluble
• オーガナイザー: GlaxoSmithKline
• 保管温度: −20°C
• SMILES記法: O=C(C[C@@H](OCC1=CC=C(C2=CC=CC=C2)C=C1)[C@H]3CC/C=C\CCC(O[Ca]OC(CC/C=C\CC[C@@H]4[C@H](OCC5=CC=C(C6=CC=CC=C6)C=C5)CC([C@H]4N7CCOCC7)=O)=O)=O)[C@H]3N8CCOCC8
• InChI: 1S/2C29H35NO5.Ca/c2*31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30;/h2*1-5,8-9,12-15,25,27,29H,6-7,10-11,16-21H2,(H,32,33);/q;;+2/p-2/b2*2-1-;/t2*25-,27-,29+;/m11./s1
• InChI Key: JDEBIDDIERGZQY-XVFRBOAOSA-L

詳細

アプリケーション

AH23848 has been used as an prostaglandin E2 receptor 4 (EP4) receptor antagonist to study its effect on cAMP accumulation in monocrotaline (MCT28d) rat pulmonary arterial smooth muscle cells (PASMCs) and human T cell enriched peripheral blood mononuclear cells (PBMC). It has also been used to study its effect on the expressions of collagen-I, metalloproteinase (MMP-1), MMP-3, and EP4 gene expression in human tendon fibroblasts following interleukin (IL)-1β treatment.

生物化学的／生理学的作用

EP₄プロスタノイドレセプタ-のアンタゴニストであり、TPをブロックする活性を有しています。

AH23848 regulates nitric oxide (NO) production and reduces endogenous cAMP accumulation. This is carried out by declination of inducible nitric oxide synthase (iNOS) gene expression and acceleration of iNOS protein degradation in glomerular mesangial cells.

特徴および利点

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)