おすすめの製品
由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified from hybridoma cell culture
抗体製品タイプ
primary antibodies
クローン
4A1/3, monoclonal
形状
buffered aqueous solution
分子量
antigen ~23 kDa
化学種の反応性
mouse, human
濃度
~1.0 mg/mL
テクニック
western blot: 2-4 μg/mL using whole extract of human Jurkat or Raji cells
アイソタイプ
IgG2a
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ASF1A(25842)
詳細
ASF1 is a histone chaperone protein that binds H3 and H4. It functions in nucleosome assembly.
Monoclonal Anti-ASF1 (mouse IgG2a isotype) is derived from the hybridoma 4A1/3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with an ASF1A fusion protein. ASF1 (anti-silencing function 1) encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast.
免疫原
ASF1A融合タンパク質
アプリケーション
Monoclonal Anti-ASF1 antibody produced in mouse has been used in immunoblotting.
生物化学的／生理学的作用
ASF1 (anti-silencing function 1) protein is a key component of a histone donor complex. It interacts with histones H3 and H4 and functions together with a chromatin assembly factor 1 (CAF-1) during DNA replication and repair. ASF1 also contributes to genome stability during S phase. Cells lacking ASF1 were found to be sensitive to a number of genotoxic agents that predominantly cause DNA damage by interfering with DNA replication fork progression such as hydroxyurea and camptothecin.
物理的形状
0.01M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
A5236-200UL:
A5236-BULK:
A5236-25UL:
A5236-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
ANTI-SILENCING FUNCTION1 proteins are involved in ultraviolet-induced DNA damage repair and are cell cycle regulated by E2F transcription factors in Arabidopsis
Lario LD, et al.
Plant Physiology, 162(2), 1164-1177 (2013)
Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C
Franco AA, et al.
Genes & Development, 19(11), 1365-1375 (2005)
Differential requirements for Tousled-like kinases 1 and 2 in mammalian development
Segura-BS, et al.
Cell Death and Differentiation, 24(11), 1872-1872 (2017)
Sandra Segura-Bayona et al.
Cell death and differentiation, 24(11), 1872-1885 (2017-07-15)
The regulation of chromatin structure is critical for a wide range of essential cellular processes. The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 chaperone, and likely other substrates, and their activity has been implicated in transcription, DNA
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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