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由来生物
goat
品質水準
結合体
agarose conjugate
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
secondary antibodies
クローン
polyclonal
フォーム
saline suspension
化学種の反応性
mouse
標識化の程度
≥5 mg per mL
テクニック
Ouchterlony double diffusion: suitable
キャパシティ
0.4 mg binding capacity
保管温度
2-8°C
ターゲットの翻訳後修飾
unmodified
関連するカテゴリー
詳細
IgM exists as a pentamer and is secreted by peritoneal B cells. IgM is a highly conserved antibody in vertebrates and is expressed early during immune response.
IgM is a glycoprotein antibody that regulates humoral immune responses. Mouse IgM is involved in modulating B cell memory. This antibody isotype has also been implicated in the development of autoimmune responses associated with the pathogenesis of type 1 diabetes in mice.
Goat anti-mouse IgM (μ-chain specific)-agarose antibody is specific for mouse IgM when tested against purified mouse IgA, IgG (all subclasses), and IgM myeloma proteins.
Goat anti-mouse IgM (μ-chain specific)-agarose antibody is specific for mouse IgM when tested against purified mouse IgA, IgG (all subclasses), and IgM myeloma proteins.
アプリケーション
Anti-Mouse IgM (μ-chain specific)−Agarose antibody produced in goat has been used in agarose binding assay in primary splenic cells and in immunoprecipitation of soluble lens protein and myelogenous leukemia cell lines.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Chromatin immunoprecipitation (1 paper)
Chromatin immunoprecipitation (1 paper)
Goat anti-mouse IgM (μ-chain specific)-agarose antibody has been used for immunoprecipitation and ChIP assays. The product can also be used for Ouchterlony double diffusion applications.
To isolate chimeric proteins that were fused with the IgM heavy chain, CHO supernatant was ran over a column packed with agarose-linked goat anti-mouse IgM mu chain specific.
生物化学的／生理学的作用
IgM displays polyreactive and autoreactive functionality. It plays a key role in tissue homeostasis by mediating clearance of tissue based molecules. IgM has sites for N-linked glycosylation, with sugars namely, mannose, galactose, N-acetyl glucosamine and sialic acid IgM plays a key role in the engulfing of apoptotic cells. A reduction in serum IgM levels leads to increased autoimmune response and higher risk for infections. IgM linked agarose resin have been tested for efficient conjugate binding.
物理的形状
Suspension in 0.5 M NaCl containing preservative.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
労働安全衛生法名称等を表示すべき危険物及び有害物
名称等を表示すべき危険物及び有害物
労働安全衛生法名称等を通知すべき危険物及び有害物
名称等を通知すべき危険物及び有害物
Jan Code
A4540-5ML:4548173185927
A4540-BULK:
A4540-25ML:4548173185903
A4540-2ML:4548173185910
A4540-VAR:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
O-GlcNAc transferase and O-GlcNAcase interact with Mi2beta at the Agamma-globin promoter
Zhang Z, et al.
The Journal of Biological Chemistry, jbc-M116 (2016)
Miltiadis Kininis et al.
Molecular and cellular biology, 29(5), 1123-1133 (2008-12-24)
Under classical models for signal-dependent transcription in eukaryotes, DNA-binding activator proteins regulate the recruitment of RNA polymerase II (Pol II) to a set of target promoters. However, recent studies, as well as our results herein, show that Pol II is
James P Hewitson et al.
Journal of immunology (Baltimore, Md. : 1950), 187(9), 4764-4777 (2011-10-04)
Heligmosomoides polygyrus is a widely used gastrointestinal helminth model of long-term chronic infection in mice, which has not been well-characterized at the antigenic level. We now identify the major targets of the murine primary Ab response as a subset of
A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens
Wyatt K, et al.
The Journal of Biological Chemistry, 283(10), 6607-6615 (2008)
Juraj Adamik et al.
Cytokine, 64(1), 404-412 (2013-06-27)
Prostaglandin E2 (PGE2), IL-23 and IL-1β are implicated in inflammatory bowel disease susceptibility, likely in part by modulating IL-17 producing CD4(+) T helper (Th17) cells. To better understand how these three mediators affect Th17 cell memory responses, we characterized the
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