479M-9

MDM2 (IF2) Mouse Monoclonal Antibody

• 別名: Mouse double minute protein 2
• UNSPSCコード: 12352203

特性

• 由来生物: mouse
• 品質水準: 100; 500
• 結合体: unconjugated
• 抗体製品の状態: culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: IF2, monoclonal
• 詳細: For In Vitro Diagnostic Use in Select Regions
• フォーム: buffered aqueous solution
• 交差性: human
• 包装: vial of 0.1 mL concentrate (479M-94); vial of 0.1 mL concentrate Research Use Only (479M-94-RUO); vial of 0.5 mL concentrate (479M-95); vial of 1.0 mL concentrate (479M-96); vial of 1.0 mL concentrate Research Use Only (479M-96-RUO); vial of 1.0 mL pre-dilute Research Use Only (479M-97-RUO); vial of 1.0 mL pre-dilute ready-to-use (479M-97); vial of 7.0 mL pre-dilute ready-to-use (479M-98); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (479M-98-RUO)
• メーカー／製品名: Cell Marque^®
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• アイソタイプ: IgG
• コントロール: dedifferentiated liposarcoma, well-differentiated liposarcoma
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 視覚化: nuclear

詳細

詳細

Mouse double minute protein 2 (MDM2) is a gene encoded on the 12q13-14 chromosomal sequence.1-5 It encodes for a 483 amino acid residue protein which binds to the amino-terminal transcription region of p53.^2,5 MDM2 has been shown to negatively regulate the tumor-suppressor activity of p53 by three mechanisms: Blocking p53 transcription, binding to p53 causing it to be exported from the nucleus, and accelerating the destruction of p53.¹ MDM2 up-regulation has been shown in liposarcoma while being absent in lipoma.^2,4 Therefore, anti-MDM2 has been demonstrated to be a potentially useful tool in distinguishing well-differentiated liposarcoma (atypical lipomatous tumor) from lipoma, with the neoplastic cells positive in the former lesion and negative in lipoma.^2,4

品質

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

調製ノート

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その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany