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由来生物
mouse
品質水準
100
500
結合体
unconjugated
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
16/f5, monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
形状
buffered aqueous solution
化学種の反応性
human
包装
vial of 0.1 mL concentrate (376M-94)
vial of 0.5 mL concentrate (376M-95)
bottle of 1.0 mL predilute (376M-97)
vial of 1.0 mL concentrate (376M-96)
bottle of 7.0 mL predilute (376M-98)
メーカー／製品名
Cell Marque™
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
アイソタイプ
IgG1κ
コントロール
breast, pancreatic ductal adenocarcinoma, urothelial carcinoma
輸送温度
wet ice
保管温度
2-8°C
視覚化
cytoplasmic, nuclear
遺伝子情報
human ... S100P(6286)
詳細
S100P is a member of the S100 family of proteins. The family is expressed in a wide range of cells and is thought to play a role in cell cycle progression and in differentiation. S100P was initially identified in the placenta at rather high levels. Anti-S100P with nuclear or nuclear/ cytoplasmic immunoreactivity can be seen in essentially 100% of pancreatic ductal adenocarcinoma in pancreatic resection, and fine needle aspiration biopsy specimens. Anti-S100P displays no staining in the benign pancreatic ducts and acinar glands. S100P has been detected in the cells of virtually all intraductal papillary mucinous neoplasms tested. S100P is clearly expressed in the invasive component of intraductal papillary mucinous neoplasms (100%), including perineural, lymphatic, and minimal invasion. Biopsies of bile ducts with primary adenocarcinomas (90%) have exhibited strong nuclear and cytoplasmic staining for anti-S100P, with none of the 32 benign biopsies exhibiting anti-S100P immunoreactivity. An immunohistochemical panel including anti-S100P can be helpful in distinguishing adenocarcinoma from reactive epithelial changes on challenging bile duct biopsies. The detection of S100P expression may help distinguish urothelial carcinomas from other genitourinary neoplasms that enter into the differential diagnosis.
品質
 IVD |  IVD |  IVD |  RUO |
関連事項
S100P Positive Control Slides, Product No. 376S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法的情報
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Tatjana Crnogorac-Jurcevic et al.
The Journal of pathology, 201(1), 63-74 (2003-09-02)
In order to expand our understanding of the molecular changes underlying the complex pathology of pancreatic malignancy, global gene expression profiling of pancreatic adenocarcinoma compared with normal pancreatic tissue was performed. Human cDNA arrays comprising 9932 elements were interrogated with
Kohei Nakata et al.
Human pathology, 41(6), 824-831 (2010-02-16)
Intraductal papillary mucinous neoplasms of the pancreas are subclassified based on morphological features, and different immunohistochemical profiles have been identified in association with the subtypes. We previously reported that S100P was an early developmental marker of pancreatic carcinogenesis and that
Mary Levy et al.
Human pathology, 41(9), 1210-1219 (2010-04-13)
Histopathologic distinction between benign and malignant bile duct epithelial lesions on endoscopic biopsies can be extremely challenging because of limited material, crush artifact, and compounding inflammatory and/or reactive changes particularly after stent placement. In this study, a total of 72
John P T Higgins et al.
The American journal of surgical pathology, 31(5), 673-680 (2007-04-27)
The morphologic distinction between prostate and urothelial carcinoma can be difficult. To identify novel diagnostic markers that may aid in the differential diagnosis of prostate versus urothelial carcinoma, we analyzed expression patterns in prostate and bladder cancer tissues using complementary
Hongbing Deng et al.
American journal of clinical pathology, 129(1), 81-88 (2007-12-20)
Even though the cytologic criteria for pancreatic ductal adenocarcinoma (PDA) on fine-needle aspiration biopsy (FNAB) specimens have been well defined, a diagnostic challenge is still present. We immunohistochemically evaluated the diagnostic value of S100P on cell-block and/or smear preparations in
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