311R-1

PAX-2 (EP235) Rabbit Monoclonal Primary Antibody

• UNSPSCコード: 12352200
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100; 500
• 結合体: unconjugated
• 抗体製品の状態: culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: EP235, monoclonal
• 詳細: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• 形状: buffered aqueous solution
• 化学種の反応性: human
• 包装: bottle of 1.0 mL predilute (311R-17); bottle of 7.0 mL predilute (311R-18); vial of 0.1 mL concentrate (311R-14); vial of 0.5 mL concentrate (311R-15); vial of 1.0 mL concentrate (311R-16)
• メーカー／製品名: Cell Marque^™
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
• アイソタイプ: IgG
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 遺伝子情報: human ... PAX2(5076)

詳細

詳細

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.¹ Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.² More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).³

品質

IVD

IVD

IVD

RUO

関連事項

PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

調製ノート

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany