Y0001790

Thiocolchicoside crystallised from ethanol

European Pharmacopoeia (EP) Reference Standard

• 別名: Thiocolchicoside, (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• 実験式（ヒル表記法）: C₂₇H₃₃NO₁₀S
• CAS番号: 602-41-5
• 分子量: 563.62
• MDL番号: MFCD07995056
• UNSPSCコード: 41116107
• PubChem Substance ID: 329831574
• NACRES: NA.24

特性

• グレード: pharmaceutical primary standard
• APIファミリー: thiocolchicoside
• メーカー／製品名: EDQM
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
• InChI Key: LEQAKWQJCITZNK-AXHKHJLKSA-N

詳細

詳細

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

アプリケーション

Thiocolchicoside crystallised from ethanol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生物化学的／生理学的作用

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

その他情報

Sales restrictions may apply.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H341,H361fd,H372
• 注意書き: P201 - P301 + P310 + P330
• 危険有害性の分類: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• ターゲットの組織: Gastro-intestinal system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable