SML1476

Thiocolchicoside

≥98% (HPLC)

• 別名: (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• 実験式（ヒル表記法）: C₂₇H₃₃NO₁₀S
• CAS番号: 602-41-5
• 分子量: 563.62
• EC Number: 210-017-7
• MDL番号: MFCD07995056
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825907
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 光学活性: [α]/D -510 to -610°, c = 0.5 in H₂O
• 色: light yellow to dark yellow
• 溶解性: H₂O: 10 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
• InChI Key: LEQAKWQJCITZNK-AXHKHJLKSA-N

詳細

生物化学的／生理学的作用

Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H341,H361fd,H372
• 注意書き: P201 - P301 + P310 + P330
• 危険有害性の分類: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• ターゲットの組織: Gastro-intestinal system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable