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品質水準
アッセイ
≥95% (NMR)
形状
solid
色
white to pale yellow
保管温度
2-8°C
SMILES記法
OC(=O)CNC(=O)C1=CC=CC(O)=C1
InChI
1S/C9H9NO4/c11-7-3-1-2-6(4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
InChI Key
XDOFWFNMYJRHEW-UHFFFAOYSA-N
詳細
3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine. 3-Hydroxyhippuric acid is an organic acid found in normal human urine. 3-Hydroxyhippuric acid is a metabolite of rutin detected in urine after consumption of tomato juice (a source of rutin). 3-Hydroxyhippuric acid has its origin in dietary procyanidins (a major source of polyphenols consisting of elementary flavan-3-ol (epi)catechin units). 3-Hydroxyhippuric acid is a microbial aromatic acid metabolite derived from dietary polyphenols and flavonoids, found in normal human urine. It is a marker of gut Clostridium species. Higher levels are associated with higher levels of Clostridia.
アプリケーション
3-Hydroxyhippuric acid is a versatile molecule and it finds application in microbiome, biochemical and metabolomics research.
特徴および利点
- Can be used in Metabolomics and Biochemical research
- High-quality compound suitable for multiple research applications
その他情報
For additional information on our range of Biochemicals, please complete this form.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SMB00940-250MG:
SMB00940-BULK:
SMB00940-50MG:
SMB00940-VAR:
最新バージョンのいずれかを選択してください：
Xiyue Xiong et al.
BioMed research international, 2016, 9485412-9485412 (2016-04-29)
Autism spectrum disorders (ASDs) are a group of mental illnesses highly correlated with gut microbiota. Recent studies have shown that some abnormal aromatic metabolites in autism patients are presumably derived from overgrown Clostridium species in gut, which may be used
Marie-Paule Gonthier et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 789(2), 247-255 (2003-05-14)
An HPLC-ESI-MS-MS method was developed to quantify in human urine fourteen aromatic acids known as metabolites of dietary polyphenols. These metabolites were determined simultaneously in a single 20-min chromatographic analysis with multiple reaction monitoring detection. The inter- and intra-day precisions
Marie-Paule Gonthier et al.
Free radical biology & medicine, 35(8), 837-844 (2003-10-15)
Procyanidins are major dietary polyphenols made of elementary flavan-3-ol (epi)catechin units. They have antioxidant properties and may contribute to health benefits in humans, but little is known about their metabolic fate. We compared here the metabolism of procyanidin dimer B3
Indu B Jaganath et al.
Free radical research, 40(10), 1035-1046 (2006-10-04)
Tomato juice containing rutin (quercetin-3-rutinoside) was ingested by healthy volunteers and ileostomists. Blood and urine collected over 24 h were analysed by HPLC with photodiode array (PDA) and tandem mass spectrometric detection. Low concentrations of isorhamnetin-3-glucuronide (Cmax = 4.3 +/-
Andreas R Rechner et al.
Free radical research, 36(11), 1229-1241 (2003-02-21)
Berry extracts rich in anthocyanins have been linked to protective effects including the modulation of age-related neurological dysfunction and the improvement of the resistance of red blood cells against oxidative stress in vitro. In this study the bioavailability, metabolism and
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