PHR3051

ミトキサントロン 二塩酸塩

pharmaceutical secondary standard, certified reference material

• 別名: 1,4-ジヒドロキシ-5,8-ビス[[2-[(2-ヒドロキシエチル)アミノ]エチル]アミノ]-9,10-アントラセンジオン 二塩酸塩
• 実験式（ヒル表記法）: C₂₂H₂₈N₄O₆ · 2HCl
• CAS番号: 70476-82-3
• 分子量: 517.40
• MDL番号: MFCD00242943
• UNSPSCコード: 41116107

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to USP 1445200
• CofA: current certificate can be downloaded
• 包装: pkg of 50 mg
• アプリケーション: pharmaceutical
• SMILES記法: Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
• InChI: 1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
• InChI Key: ZAHQPTJLOCWVPG-UHFFFAOYSA-N

詳細

詳細

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

アプリケーション

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

ミトキサントロンは、細胞増殖抑制性アントラセンジオンであり、DNAにインターカレートし、トポイソメラーゼIIとDNAの開裂可能な複合体を安定化することによって、2本鎖切断の発生率を高めます。ミトキサントロンは、幅広い免疫抑制作用も示し、すべての種類のリンパ球の増殖を阻害し、抗原提示T細胞のアポトーシスを誘導します。臨床では、白血病や固形腫瘍に対する化学療法剤として、また多発性硬化症における免疫系修飾薬として使用されます。

アナリシスノート

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H340 - H360
• 注意書き: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Muta. 1B - Repr. 1B
• 保管分類コード: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable