PHR1384

アミトリプチリン 塩酸塩

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: Amitriptyline hydrochloride, 10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptane-Δ5γ-propylamine hydrochloride, 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
• 実験式（ヒル表記法）: C₂₀H₂₃N · HCl
• CAS番号: 549-18-8
• 分子量: 313.86
• EC Number: 208-964-6
• MDL番号: MFCD00012537
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823361
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 16; traceable to Ph. Eur. Y0000563; traceable to USP 1029002
• APIファミリー: amitriptyline
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
• InChI Key: KFYRPLNVJVHZGT-UHFFFAOYSA-N
• 遺伝子情報: human ... SLC6A2(6530) , SLC6A4(6532)

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amitriptyline hydrochloride is a drug, and a tricyclic antidepressant with anticholinergic activity. It is widely used in combination with chlordiazepoxide 7-chloro-2-(methyl-amino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.

アプリケーション

Amitriptyline hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

三環系抗うつ薬であり、ノルエピネフリントランスポ-タ-、セロトニントランスポ-タ-を、それぞれK_i= 100nM, 14.7nMで阻害するインヒビタ-です。 in vitro でα₁-アドレナリンレセプタ-、セロトニンレセプタ-、ムスカリン性アセチルコリンレセプタ-に高い親和性があります。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA1640 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS06,GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H301,H319,H361fd,H410
• 注意書き: P202 - P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable