90833

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid

analytical standard

• 別名: 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF, Propylurofuranic acid
• 実験式（ヒル表記法）: C₁₂H₁₆O₅
• CAS番号: 86879-39-2
• 分子量: 240.25
• MDL番号: MFCD08436079
• UNSPSCコード: 12352106
• NACRES: NB.21

特性

• グレード: analytical standard
• 品質水準: 100
• アッセイ: ≥95.0% (HPLC)
• シェルフライフ: limited shelf life, expiry date on the label
• アプリケーション: clinical testing
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: OC(CCC1=C(C(O)=O)C(C)=C(CCC)O1)=O
• InChI: 1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
• InChI Key: WMCQWXZMVIETAO-UHFFFAOYSA-N

詳細

詳細

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a major metabolite of furan fatty acids, is a uremic toxin (UT), excreted into the urine via organic,anion transporters under physiological conditions. It is mostly reported to be accumulated in chronic kidney disease (CKD) patients. Monitoring of CMPF may be important to predict organic anion transporting polypeptide (OATP)1B activity in CKD patients as studies have implicated a decreased trend in (OATP)1B activity in patients with this uremic toxin. It is also found to be in increased concentrations, for patients who progress from prediabetes to type 2 diabetes, patients with renal failure, polyunsaturated fatty acids with high-temperature cooking and subjects who consume fish or fish oil.

アプリケーション

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid may be used as an analytical reference standard for the quantification of the analyte in human plasma samples using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3