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About This Item
実験式（ヒル表記法）:
C20H26O4
CAS番号:
分子量:
330.42
MDL番号:
UNSPSCコード:
85151701
PubChem Substance ID:
NACRES:
NA.24
おすすめの製品
由来生物
Rosemarinus officinalis L. leaves
品質水準
グレード
analytical standard
アッセイ
≥98.0% (HPLC)
シェルフライフ
limited shelf life, expiry date on the label
テクニック
HPLC: suitable
gas chromatography (GC): suitable
アプリケーション
food and beverages
フォーマット
neat
保管温度
−20°C
SMILES記法
CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
InChI
1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
InChI Key
XUSYGBPHQBWGAD-PJSUUKDQSA-N
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詳細
Carnosol is a naturally occurring phyto polyphenolor phenolic diterpene, found in rosemary, which can show a broad spectrum of applications as a an antioxidant, anticancer agent and anti-inflammatory agent.
Carnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis.The effective dose reported is 1-10 μM topically or 6 μg/ml when added to supernatants of cultured cells.Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-DNA adducts.
アプリケーション
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生物化学的／生理学的作用
A phenolic diterpene with antioxidant and anticarcinogenic activities.
包装
底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。
その他情報
This compound is commonly found in plants of the genus: salvia
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Skin Sens. 1
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
49702-10MG:
49702-BULK:
49702-VAR:
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Ai-Hsiang Lo et al.
Carcinogenesis, 23(6), 983-991 (2002-06-26)
Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH)
Carnosol: a promising anti-cancer and anti-inflammatory agent
Johnson.JJ
Cancer Letters, 305, 1-7 (2011)
Shiu-Chen Huang et al.
Biochemical pharmacology, 69(2), 221-232 (2005-01-04)
Carnosol, a constant constituent of Rosmarinus officinalis extracts, is a phenolic diterpene shown to have antioxidant and anticarcinogen properties. In our studies, carnosol inhibited the invasion of highly metastatic mouse melanoma B16/F10 cells in vitro. First, the antimetastatic potentials of
Kai-Cheng Lian et al.
Toxicology and applied pharmacology, 245(1), 21-35 (2010-02-02)
The increased adhesion of monocytes to injured endothelial layers is a critical early event in atherogenesis. Under inflammatory conditions, there is increased expression of specific cell adhesion molecules on activated vascular endothelial cells, which increases monocyte adhesion. In our current
Sang Yong Kim et al.
Journal of agricultural and food chemistry, 58(3), 1543-1550 (2010-01-16)
Carnosol, a naturally occurring bioactive phenolic diterpene originating from rosemary and sage, has been shown to exert antioxidant and anti-inflammatory effects. This study examined possible protective effects of carnosol on sodium nitroprusside (SNP)-induced cytotoxicity in C6 glial cells. Carnosol (1-10
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