SCC201

LOX-IMVI Human Melanoma Cell Line

Human

• 別名: LOX/IMVI, LOX IMVI, LOXIM-VI, LOXIMVI
• UNSPSCコード: 41106514
• eCl@ss: 32011203
• NACRES: NA.81

特性

• 製品名: LOX-IMVI Human Melanoma Cell Line, LOX-IMVI human melanoma cell line is an excellent model for probing mechanisms of metastasis and for evaluation of chemotherapies.
• 由来生物: human
• テクニック: cell culture | mammalian: suitable

詳細

詳細

Malignant melanoma is highly treatable when diagnosed early, but can spread rapidly if undetected, resulting in the highest mortality among skin cancer types. Lymph nodes and lungs are the most common sites of melanoma metastases , and because of the poor prognosis and limited efficacy of current treatments, metastatic melanoma has generated intense interest as a target for therapeutic intervention.

The LOX-IMVI human melanoma cell line is widely used as an in vitro model system to study tumor metastasis and to test for chemosensitivity to potential anti-cancer compounds. LOX-IMVI cells exhibit a tendency to form lung metastases in nude mice independent of the inoculation site , and mortality of experimental animals is observed within 3-5 weeks of LOX-IMVI cell injection . LOX-IMVI cells are genetically characterized by lack of the Y chromosome and trisomy 7 , and are heterozygous for the BRAF V600E melanoma driver mutation . LOX-IMVI cells are amelanotic and express the human melanoma marker GD3 ganglioside, a factor in metastatic potential of malignant melanoma .

Source:
The LOX-IMVI human melanoma cell line was established from a subcutaneous xenograft in nude mice from a lymph node metastasis of a 58-year-old Caucasian male patient with malignant amelanotic melanoma .

細胞株の説明

Cancer Cells

アプリケーション

Research Category
がん

LOX-IMVI human melanoma cell line is an excellent model for probing mechanisms of metastasis and for evaluation of chemotherapies.

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

品質

• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
• Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

保管および安定性

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable