MABT153

Anti-Aggrecan Antibody (full length), clone 4D7.1

clone 4D7.1, 1 mg/mL, from mouse

• 別名: Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: 4D7.1, monoclonal
• 化学種の反応性: human
• 濃度: 1 mg/mL
• テクニック: western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_037359
• UniProtアクセッション番号: P16112
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ACAN(176)

詳細

詳細

Aggrecan is an extracellular protein that is also known as Aggrecan core protein, Cartilage-specific proteoglycan core protein (CSPCP), Chondroitin sulfate proteoglycan core protein 1, and Chondroitin sulfate proteoglycan 1. Aggrecan is encoded by the gene ACAN/AGC1/CSPG1/MSK16. Aggrecan is a proteoglycan that is a major component of the extracellular matrix of cartilaginous tissues. The major function of Aggrecan is to resist compression in cartilage, thus providing protection for joint movement and against injury. Aggrecan binds various other ECM proteins via its large globular domains. Aggrecan can be cleaved into Aggrecan core protein 2, a C-terminal fragment component that decreases in cartilage as people age. Aggrecan is expressed in cartilage and is a massive (>2500 kDa) proteoglycan protein that has multiple isoforms. The appearance of Aggrecan fragments in the blood is a marker for various joint diseases.

免疫原

KLH-conjugated linear peptide corresponding to human Aggrecan.

アプリケーション

Research Category
細胞骨格

Research Sub Category
ECMタンパク質

This Anti-Aggrecan Antibody (full length), clone 4D7.1 is validated for use in Western Blotting for the detection of Aggrecan (full length).

品質

Evaluated by Western Blotting in human chondrocyte cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Aggrecan (full length) in 10 µg of human chondrocyte cell lysate.

ターゲットの説明

~270 kDa observed. The calculated molecular weight is 250 kDa However, this protein is known to be highly glycosylated and may be observed at higher molecular weights.

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable