MABT1497

Anti-P40 (TP63) Antibody, clone 11H1

clone 11H1, from mouse

• 別名: Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, P51
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 11H1, monoclonal
• 化学種の反応性: human
• 包装: antibody small pack of 25 μL
• テクニック: western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_001108452
• UniProtアクセッション番号: Q9H3D4
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TP63(8626)

詳細

詳細

Tumor protein 63 (UniProt: Q9H3D4; also known as p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, P40, P51) is encoded by the TP63 (also known as KET, P63, P73H, P73L, TP73L) gene (Gene ID: 8626) in human. TP63 is a member of the p53 protein family that is widely expressed. TP63 acts as a sequence specific DNA binding transcriptional activator or repressor. TP63 is shown to bind to DNA as a homotetramer and its DNA binding region is localized to amino acids 170-362. It has a transcription activation region (aa 1-107) and a transactivation inhibition region (aa 610-680), which can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA-type isoforms. Twelve different isoforms of TP63 have been described that are produced by alternative promoter usage and alternative splicing. These isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. The ratio of DeltaN-type and TA-type isoforms governs the maintenance of epithelial stem cell compartments and regulates the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Isoform 2 is reported to activate RIPK4 transcription and may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Isoform 10 is predominantly expressed in skin squamous cell carcinoma, but not in normal skin tissue.

特異性

Clone 11H1 detects human Tumor protein 63 (P40). It targets an epitope with in the first 205 amino acids from the N-terminal region.

免疫原

Epitope: N-terminus

MBP-conjugated recombinant fragment corresponding to the first 205 amino acids from human Tumor protein 63.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Anti-P40 (TP63), clone 11H1, Cat. No. MABT1497, is a mouse monoclonal antibody that detects Tumor protein 63 and has been tested for use in Western Blotting.

品質

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:250 dilution of this antibody detected P40 (TP63) in A431 cell lysate.

ターゲットの説明

~66 kDa observed; 76.78 kDa calculated.Uncharacterized bands may be observed in some lysate(s).

物理的形状

Protein G purified

Format: Purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.