おすすめの製品
由来生物
mouse
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
44G4, monoclonal
交差性
human
テクニック
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
アイソタイプ
IgG1κ
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ENG(2022)
詳細
Endoglin (CD105) is a homodimeric integral membrane glycoprotein comprised of a 95 kDa subunit. Endoglin is a component of the TGF-β receptor system that functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-β) family of ligands to signaling receptors. Endoglin binds to TGF-β1 and TGF-β3 with high affinity, but does not bind TGF-β2. Endoglin is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. Endoglin is also expressed by U937 cells and by activated macrophages. Endoglin expression is up-regulated on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.
免疫原
Whole HOON Pre-B Leukemic Cells
アプリケーション
Research Category
細胞骨格
細胞骨格
Research Sub Category
接着分子（CAM）
接着分子（CAM）
Anti-Endoglin (CD105) Antibody, clone 44G4 is an antibody against Endoglin (CD105) for use in FC, IH & IP.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory to detect Endoglin in normal human lymph node, tonsil, spleen thrymus, liver, breast, lung, and kidney specimens (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to IP Endoglin from HOON, NALM-6, 3104, 3161, HL-60, U-937, EM-3 and KG-1a cells (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to IP Endoglin from HOON, NALM-6, 3104, 3161, HL-60, U-937, EM-3 and KG-1a cells (Gougos, A., and Letarte, M. (1988). J Immunol. 141(6):1925-1933).
品質
Evaluated by Flow Cytometry in HUVEC cells.
Flow Cytometry Analysis: A 1:200 dilution of this antibody detected Endoglin in HUVEC cells.
Flow Cytometry Analysis: A 1:200 dilution of this antibody detected Endoglin in HUVEC cells.
ターゲットの説明
71 kDa calculated
物理的形状
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
保管および安定性
Stable for 1 year at 2-8°C from date of receipt.
アナリシスノート
Control
HUVEC cells
HUVEC cells
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MABT117:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
José M Díez et al.
Stem cell research & therapy, 6, 28-28 (2015-04-19)
Fetal bovine serum (FBS) is an animal product used as a medium supplement. The animal origin of FBS is a concern if cultured stem cells are to be utilized for human cell therapy. Therefore, a substitute for FBS is desirable.
Arantxa Blázquez-Prunera et al.
Stem cell research & therapy, 8(1), 103-103 (2017-04-30)
Mesenchymal stem cells (MSCs) show promising characteristics for their use in advanced therapy medicinal products. However, there are some unresolved concerns, such as the use of animal components for their expansion. In this study we assessed the suitability of a
Qiuyun Li et al.
Molecular medicine reports, 24(3) (2021-07-24)
Hepatic ischemia/reperfusion injury (HIRI) is a complex pathophysiological process that may develop after liver transplantation and resection surgery, as well as in uncontrolled clinical conditions. Bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are potential targets for liver diseases. Thus, the present
資料
PLTMax® Human Platelet Lysate (hPL) is a superior serum-free and xeno-free media supplement alternative to fetal bovine serum (FBS) for human mesenchymal stem cell (MSC) cultures.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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