MABN2263

Anti-ZMYM2 Antibody, clone 9F12.1

clone 9F12.1, from mouse

• 別名: Zinc finger MYM-type protein 2, Fused in myeloproliferative disorders protein, Rearranged in atypical myeloproliferative disorder protein, Zinc finger protein 198
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: 9F12.1, monoclonal
• 交差性: human
• 包装: antibody small pack of 25 μg
• テクニック: western blot: suitable
• アイソタイプ: IgG2aκ
• NCBIアクセッション番号: NP_001177893
• UniProtアクセッション番号: Q9UBW7
• 輸送温度: ambient
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ZMYM2(7750)

詳細

詳細

Zinc finger MYM-type protein 2 (UniProt: Q9UBW7; also known as Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198) is encoded by the ZMYM2 (also known as FIM, RAMP, ZNF198) gene (Gene ID: 7750) in human. Zinc finger MYM-type protein 2 is a nuclear protein that may function as a transcription factor. Two isoforms of Zinc finger MYM-type protein 2 have been described that are produced by alternative splicing. The SUMO-interacting motifs (SIM) of Zinc finger MYM-type protein 2 are shown to be essential for its recruitment to chromatin. The SIM motifs play an important role in its gene-regulatory activities, however, they are not required for the intrinsic transcriptional repressive properties of Zinc finger MYM-type protein 2. A chromosomal aberration involving ZMYM2 is reported to cause stem cell leukemia lymphoma syndrome (SCLL), which is characterized as lymphoblastic lymphoma in association with a myeloproliferative disorder accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. (Ref.: Aguilar-Martinez, E., et al. (2015). Proc. Natl. Acad. Sci. USA. 112 (35); E4854-E4863).

特異性

Clone 9F12.1 detects Zinc finger MYM-type protein 2 in human cells. It targets an epitope within 167 amino acids from the C-teminal region.

免疫原

GST/His-tagged recombinant fragment corresponding to 167 amino acids from the C-terminal region of human Zinc finger MYM-type protein 2.

アプリケーション

Anti-ZMYM2, clone 9F12.1, Cat. No. MABN2263, is a highly specific mouse monoclonal antibody that targets Zinc finger MYM-type protein 2 and has been tested in Western Blotting.

品質

Evaluated by Western Blotting in human hippocampus tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected ZMYM2 in human hippocampus tissue lysate.

ターゲットの説明

~155 kDa observed; 154.91 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

物理的形状

Format: Purified

その他情報

Concentration: Please refer to lot specific datasheet.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): does not flash
• 引火点(℃): does not flash