MABF517

Anti-CD11b Antibody (human/mouse), PerCP-Cy5.5, clone M1/70

clone M1/70, 0.2 mg/mL, from rat

• 別名: Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD antigen CD11b
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rat
• 品質水準: 100
• 結合体: PerCP-Cy5.5
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: M1/70, monoclonal
• 化学種の反応性: mouse, human
• 包装: antibody small pack of 25 μg
• 濃度: 0.2 mg/mL
• テクニック: flow cytometry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• アイソタイプ: IgG2bκ
• UniProtアクセッション番号: P05555; P11215
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ITGAM(3684)

詳細

詳細

The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling throµgh ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.

免疫原

Immunogen information for this antibody is proprietary information.

アプリケーション

Research Category
炎症及び免疫

This rat monoclonal antibody Anti-CD11b (human/mouse), PerCP-Cy5.5, clone M1/70 validated for use in IP, IHC, Flow Cytometry & Immunofluorescence for the detection of CD11b.

品質

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 µg of this antibody detected CD11b in one million C57Bl/6 bone marrow cells.

物理的形状

Size Exclusion Chromatography

Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.

保管および安定性

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable