MABF369

Anti-CD11c Antibody (human), PE-Cy7, clone 3.9

clone 3.9, from mouse

• 別名: Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, 95, CD antigen CD11c
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.44

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: PE-Cy7
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: 3.9, monoclonal
• 化学種の反応性: human
• 包装: pkg of 5 μL (1 μg/test)
• テクニック: flow cytometry: suitable; immunofluorescence: suitable; immunoprecipitation (IP): suitable
• アイソタイプ: IgG1κ
• UniProtアクセッション番号: P20702
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ITGAX(3687)

詳細

詳細

The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.

アプリケーション

This Mouse Monoclonal Antibody Anti-CD11c (human), PE-Cy7, clone 3.9, Cat. No. MABF369 is validated for use in IP, IF, FC for the detection of CD11c.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable