MABE988

Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1

clone 7D9.1, from mouse

• 別名: Homeobox protein CDX-2, Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 7D9.1, monoclonal
• 化学種の反応性: human
• テクニック: immunohistochemistry: suitable (paraffin); western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_001256
• UniProtアクセッション番号: Q99626
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CDX2(1045)

詳細

詳細

Homeobox protein CDX-2 (UniProt Q99626; also known as Caudal-type homeobox protein 2, Caudal type homeobox transcription factor 2, CDX-3) is encoded by the CDX2 (also known as CDX3, CDX2/AS) gene (Gene ID 1045) in human. CDX-2 is a transcription factor that plays an important role during embryonic development, where it determines intestinal identity in the presumptive gut endoderm. CDX-2 is also required for maintenance of intestinal identity in the intestinal epithelium throughout adulthood. Mitogen-activated protein kinases (MAPK) are reported to modulate CDX2 transcriptional activity and half-life via phosphorylation. Reduction of CDX2 expression facilitates tumor progression in murine models of colorectal cancer (CRC) and decreased CDX2 expression level in CRC correlates with poor prognosis in human.

免疫原

Epitope: Internal

GST-tagged recombinant protein corresponding to human Homeobox protein CDX-2.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
核受容体

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Homeobox protein CDX-2 in human colon and human colorectal cancer tissue.

This Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Homeobox protein CDX-2.

品質

Evaluated by Western Blotting in human colorectal adenocarcinoma DLD-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Homeobox protein CDX-2 in 10 µg of human colorectal adenocarcinoma DLD-1 cell lysate.

ターゲットの説明

~35/39 kDa observed. Target band often appears as a doublet due to posttranslational modifications (phosphorylations & polyubiquitinations).

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable