MABE902

Anti-Pax-2 Antibody, clone 4C2.2

culture supernatant, clone 4C2.2, from mouse

• 別名: Paired box protein Pax-2, Pax-2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: 4C2.2, monoclonal
• 化学種の反応性: human
• テクニック: western blot: suitable
• アイソタイプ: IgG2bκ
• NCBIアクセッション番号: NP_000269
• UniProtアクセッション番号: Q02962
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PAX2(5076)

詳細

詳細

Paired box protein Pax-2 (UniProt Q02962; also known as Paired box homeotic gene 2) is encoded by the PAX2 (also known as FSGS7, PAPRS) gene (Gene ID 5076) in human. Pax-2 belongs to the family of transcription factors with conserved DNA-binding paired box domain. The family of paired box (PAX) genes is divided into four subgroups (I–IV). Genes in subgroups II (PAX2, PAX5, and PAX8) and III (PAX3 and PAX7) have been implicated in tumor development. PAX2 is a critical regulator of embryogenesis and it is normally expressed in the pancreas and in subpopulations of nodal lymphocytes in adult tissues. Aberrant PAX2 expression is frequently observed in several cancer types.

特異性

Clone 4C2.2 is expected to react with spliced Pax-2 isoform 1 and isoform 2 (Fetal kidney isoform). Reactivity toward isoforms 3&4 has not been tested.

免疫原

GST-tagged recombinant protein corresponding to human Pax-2.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
核受容体

This Anti-Pax-2 Antibody, clone 4C2.2 is validated for use in Western Blotting for the detection of Pax-2 .

Western Blotting Analysis: A 1:500 dilution from a representative lot detected PAX-2 in 10 µg of HeLa and PC3 cell lysate.

品質

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected PAX-2 in 10 µg of A431 cell lysate.

ターゲットの説明

~45 kDa observed. ~45 kDa observed. Isoform 1 (44.7 kDa calculated); Isoform 2 (44.5 kDa calculated). An uncharacterized band ~17 kDa is seen in some lysate samples.

物理的形状

Unpurified

Mouse monoclonal IgG2bκ antibody in buffer containing supernatant without preservatives.

保管および安定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable