MABC582

Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1

clone 11D12.1, from mouse

• 別名: Baculoviral IAP repeat-containing protein 3, Apoptosis inhibitor 2, API2, C-IAP2, IAP homolog C, Inhibitor of apoptosis protein 1, IAP-1, hIAP-1, hIAP1, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1, hIAP-1/BIRC3
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 11D12.1, monoclonal
• 交差性: human
• テクニック: western blot: suitable
• アイソタイプ: IgG1κ
• NCBIアクセッション番号: NP_001156
• UniProtアクセッション番号: Q13489
• 輸送温度: dry ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... BIRC3(330)

詳細

詳細

Baculoviral IAP repeat-containing protein 3 (UniProt Q13489; also known as API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing 3, c-IAP2, hIAP-1, hIAP1, IAP homolog C, IAP-1, Inhibitor of apoptosis protein 1, Mammalian IAP homolog C, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1) is encoded by the BIRC3 (also known as API2, AIP1, IAP1, HAIP1, HIAP1, MALT2, MIHC, RNF49) gene (Gene ID 330) in human. hIAP-1 (c-IAP2) belongs to the inhibitor of apoptosis (IAP) family of proteins characterized by the presence of at least one baculoviral IAP repeat (BIR) domain. hIAP-1 (c-IAP2 contains three BIR (BIR1/2/3) domains, followed by an UBA (ubiquitin-associated), a CARD (caspase activation and recruitment domain), and a RING (really interesting new gene) domain. The BIR domains mediate hIAP-1 interaction with various binding partners, such as caspases, other IAP family members, and receptor-associated complexes. The RING domain and its associated E3 ligase mediates not only the ubiqutination of substrate proteins, such as caspase-3, caspase-7, SMAC/DIABLO, but also self-ubiquitylation. The UBA domain enables hIAP-1 to engage protein complexes containing poly-ubiquitylated protein(s).

免疫原

GST-tagged recombinant protein corresponding to the BIR 1/2 of human hIAP-1/BIRC3.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

Detect BIRC3 using this mouse monoclonal Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1, Cat. No. MABC582, validated for use in Western Blotting.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected hIAP-1/BIRC3 in 10 µg of TF-1, Jurkat, and Molt-4 cell lysate.

品質

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected hIAP-1/BIRC3 in 10 µg of K562 cell lysate.

ターゲットの説明

~60 kDa observed

物理的形状

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable