おすすめの製品
由来生物
mouse
品質水準
抗体製品の状態
purified antibody
抗体製品タイプ
primary antibodies
クローン
11E4, monoclonal
化学種の反応性
human
メーカー／製品名
Chemicon®
テクニック
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
アイソタイプ
IgG1
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... JUP(3728)
特異性
Produced by immunization with recombinant human G-catenin.
アプリケーション
Research Category
細胞骨格
細胞骨格
Detect γ-Catenin using this Anti-γ-Catenin Antibody, clone 11E4 validated for use in IP, WB, IC, IH.
Immunohistochemistry: Histochoice fixative is effective.
Immunocytochemistry: Effective for A431 and HT1080 cell lines.
Immunoblotting
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Immunocytochemistry: Effective for A431 and HT1080 cell lines.
Immunoblotting
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Research Sub Category
Cytoskeleton
Cytoskeleton
物理的形状
Format: Purified
Liquid at 1 mg/mL in 0.02 M phosphate buffer, pH 7.6, 0.25M NaCl, containing 0.1% sodium azide.
保管および安定性
Maintain refrigerated at 2-8°C in undiluted aliquots for up to12 months.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.
Nieset, J E, et al.
Journal of Cell Science, 110 ( Pt 8), 1013-1022 (1997)
D Salomon et al.
The Journal of cell biology, 139(5), 1325-1335 (1998-01-07)
beta-Catenin and plakoglobin (gamma-catenin) are closely related molecules of the armadillo family of proteins. They are localized at the submembrane plaques of cell-cell adherens junctions where they form independent complexes with classical cadherins and alpha-catenin to establish the link with
P A Sacco et al.
The Journal of biological chemistry, 270(34), 20201-20206 (1995-08-25)
Cadherins are calcium-dependent, cell surface glycoproteins involved in cell-cell adhesion. To function in cell-cell adhesion, the transmembrane cadherin molecule must be associated with the cytoskeleton via cytoplasmic proteins known as catenins. Three catenins, alpha-catenin, beta-catenin, and gamma-catenin (also known as
Cross-talk between adherens junctions and desmosomes depends on plakoglobin.
Lewis, J E, et al.
The Journal of cell biology, 136, 919-934 (1997)
Xuming Mao et al.
The Journal of biological chemistry, 286(2), 1283-1291 (2010-11-17)
Pemphigus vulgaris (PV) is a potentially fatal blistering disease characterized by autoantibodies against the desmosomal adhesion protein desmoglein (Dsg) 3. Whether autoantibody steric hindrance or signaling through pathways such as p38 MAPK is primary in disease pathogenesis is controversial. PV
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