MAB1399Z-I

Anti-Integrin αX Antibody, clone N418 Antibody, azide free

clone N418, from hamster(Armenian)

• 別名: Integrin alpha-X, CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, 95, CD11c
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: hamster (Armenian)
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: N418, monoclonal
• 化学種の反応性: mouse
• 包装: antibody small pack of 25 μg
• テクニック: flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• アイソタイプ: IgG
• NCBIアクセッション番号: NP_067309
• UniProtアクセッション番号: Q9QXH4
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: mouse ... Itgax(16411)

詳細

詳細

Integrin alpha-X (UniProt: Q9QXH4; also known as CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11c) is encoded by the Itgax gene (gene ID: 16411) in murine species. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD11c is a single-pass type I membrane protein. It has an extracellular domain (aa 20-1116), a transmembrane domain (aa 1117-1137), and a cytoplasmic domain (aa 1138-1169). It is synthesized with a signal peptide (aa 1-19), which is subsequently cleaved off in the mature form. Low levels of CD11c are expressed on human granulocytes and monocytes, and higher expression levels are observed on macrophages, dendritic cells and hairly cell leukemias. CD11c associates with beta-2 subunit in a non-covalent manner and then serves as a receptor for fibrinogen where it recognizes the sequence G-P-R. CD11c is shown to mediate cell-cell interaction during inflammatory responses and is important in monocyte adhesion and chemotaxis. Clone N418 is known to recognize an epitope on the p150 alpha chain. (Ref.: Metlay, JP et al. (1990). J. Exp. Med. 171(5); 1753-1771).

特異性

Clone N418 is a mouse monoclonal antibody that detects integrin alpha-X in murine tissue.

免疫原

Mouse spleen dendritic cells.

アプリケーション

Research Category
炎症及び免疫

Anti-Integrin X, clone N418, azide free, Cat. No. MAB1399Z-I, is an armenian hamster monoclonal antibody that detects Integrin alpha-X and has been tested for use in Immunohistochemistry, Flow Cytometry, and Immunoprecipitation.

Immunoprecipitation Analysis: A representative lot detected Integrin X in Immunoprecipitation applications (Metlay, J.P., et. al. (1990). J Exp Med. 171(5):1753-71).

Immunohistochemistry Analysis: A representative lot detected Integrin X in Immunohistochemistry applications (Tan, C.S.E., et. al. (2017). PLoS Pathog. 13(4):e1006311; Roland, C.L., et. al. (2009). Mol Cancer Ther. 8(7):1761-71; Metlay, J.P., et. al. (1990). J Exp Med. 171(5):1753-71).

Flow Cytometry Analysis: A representative lot detected Integrin X in Flow Cytometry applications (Metlay, J.P., et. al. (1990). J Exp Med. 171(5):1753-71; Granucci, F., et. al. (1997). J Immunol. 159(4):1794-99; Cervantes-Barragan, L., et. al. (2007). Blood. 109(3):1131-37).

品質

Evaluated by Immunohistochemistry in mouse spleen frozen tissue sections.

Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected Integrin X in mouse spleen frozen tissue sections.

ターゲットの説明

129.15 kDa calculated.

物理的形状

Protein G purified

Format: Purified

Purified armenian hamster monoclonal antibody IgG in PBS without preservatives.

保管および安定性

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2