ABS796

Anti-phospho-HER4 Antibody (Tyr1162)

from rabbit, purified by affinity chromatography

• 別名: ERBB4, HER4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, ERBB4 intracellular domain, s80HER4
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: Q15303
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: phosphorylation (pTyr1162)
• 遺伝子情報: human ... ERBB4(2066)

詳細

詳細

Receptor tyrosine-protein kinase erbB-4, also known as, Proto-oncogene-like protein c-ErbB-4 (4ICD or E4ICD), and encoded by the gene names Erbb4 or Tyro-2, plays an essential role as cell surface receptor for neuregulins. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. ERBB4 is preferentially expressed in the developing nervous system. It exhibits distinct and highly regionalized patterns of expression in the adult brain, where it is mainly found in the reticular nucleus of the thalamus.

免疫原

Epitope: Phosphorylated Tyr1162

KLH-conjugated synthetic peptide corresponding to human PGK1 phosphorylated at Tyr1162.

アプリケーション

Detect HER4 using this rabbit polyclonal Anti-phospho-HER4 Antibody, Cat. No. ABS796, validated for use in Western Blotting, Immunohistochemistry, and Immunocytochemistry.

Immunohistochemistry Analysis (IHC): A 1:10-50 dilution from a representative lot detected HER4 in human cancer tissue.

Immunocytochemistry Analysis (ICC): A 1:10-50 dilution from a representative lot detected HER4 in MCF-7 cells.

品質

Evaluated by Western Blotting in untreated and EGF treated A431 cell lysates.

Western Blotting Analysis (WB): A 1:1000 dilution of this antibody detected HER4 in untreated and EGF treated A431 cell lysates.

ターゲットの説明

~160 kDa observed. Uncharacterized bands may be observed in some lysate(s).

物理的形状

Purified rabbit polyclonal in buffer containing PBS with 0.09% (W/V) sodium azide.

その他情報

Concentration: Please refer to lot specific datasheet.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable