ABN348

Anti-TTBK1 Antibody

from rabbit, purified by affinity chromatography

• 別名: Tau tubulin kinase 1, brain derived tau kinase, BDTK, TTBK1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human, mouse
• テクニック: immunohistochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: Q5TCY1
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TTBK1(84630)

詳細

詳細

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer’s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.

特異性

This antibody is predicted to not cross-react with TTBK2.

免疫原

KLH-conjugated linear peptide corresponding to human TTBK1.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
神経変性疾患

Immunohistochemistry Analysis: 2.5 µg/mL of this antibody from a representative lot detected. TTBK1 in mouse brain tissue.

This TTBK1 antibody is validated for use in WB & IHC for the detection of the TTBK1 protein.

品質

Evaluated by Western Blot in Jurkat cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected TTBK1 in 15 µg of Jurkat cell lysate.

ターゲットの説明

~143 kDa observed

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS and 0.02% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Jurkat cell lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable