ABE1387
Anti-Nuclear factor 1/C Antibody
serum, from rabbit
別名:
Nuclear factor 1 C-type, NF1-C, CCAAT-box-binding transcription factor, CCAAT-box-binding transcription factor, CTF, Nuclear factor I/C, NF-I/C, NFI-C, TGGCA-binding protein
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About This Item
UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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由来生物
rabbit
品質水準
抗体製品の状態
serum
抗体製品タイプ
primary antibodies
クローン
polyclonal
交差性
mouse, rat, human
テクニック
ChIP: suitable
electrophoretic mobility shift assay: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... NFIC(4782)
詳細
Through evolution, eukaryotic cells have incorporated numerous viral promoter elements and incorporated them as part of their own gene regulatory elements. Nuclear factor 1/C was originally recognized as a transcription factor that bound the origin of replication for adenovirus type 2. Nuclear factor 1/C belongs to the CTF/NF-I family of eukaryotic DNA replication and transcription factors and is important in regulating the expression of many cellular developmental systems such as that of tooth development as well as multiple TGF-beta1 signaling mediated pathways systems.
特異性
Recognizes multiple isoforms of Nuclear factor 1/C
免疫原
Epitope: C-terminus
Recombinant protein corresponding to full length Human NFIC.
アプリケーション
Research Category
エピジェネティクス及び核内機能分子
エピジェネティクス及び核内機能分子
Research Sub Category
転写因子
転写因子
Chromatin Immunoprecipitation Assay (ChIP): A representative lot of this antibody has been reported to work in ChIP. See Hebbar, P.B., and Archer, T.K. (2007), Vicent G.P. et al. (2010), and Brun, M., et al. (2013).
Electrophoretic Mobility Shift Assay (EMSA): A representative lot of this antibody has been reported to work in EMSA. See Johansson E.M., et al. (2003) and Kannius-Janson, M., et al. (2002).
Electrophoretic Mobility Shift Assay (EMSA): A representative lot of this antibody has been reported to work in EMSA. See Johansson E.M., et al. (2003) and Kannius-Janson, M., et al. (2002).
This Anti-Nuclear factor 1/C Antibody is validated for use in Western Blotting and Chromatin Immunoprecipitation (ChIP) and Electrophoretic Mobility Shift Assay for the detection of Nuclear factor 1/C.
品質
Evaluated by Western Blotting in U251 cell lysate.
Western Blotting Analysis: A 1:1000 dilution of this antibody detected NFIC isoforms at ~45-55 kDa in a U251 cell lysate.
Western Blotting Analysis: A 1:1000 dilution of this antibody detected NFIC isoforms at ~45-55 kDa in a U251 cell lysate.
ターゲットの説明
~45-55 kDa observed
物理的形状
Unpurified
Rabbit polyclonal serum containing 0.05% sodium azide.
保管および安定性
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
その他情報
Concentration: Please refer to lot specific datasheet.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
ABE1387:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Pratibha B Hebbar et al.
The Journal of biological chemistry, 282(11), 8284-8291 (2006-12-26)
Accessing binding sites in DNA wrapped around histones in condensed chromatin is an obstacle that transcription factors must overcome to regulate gene expression. Here we demonstrate cooperativity between two transcription factors, the glucocorticoid receptor (GR) and nuclear factor 1 (NF1)
Marie Kannius-Janson et al.
The Journal of biological chemistry, 277(20), 17589-17596 (2002-03-06)
Members of the nuclear factor 1 (NF1) transcription factor family have been postulated to be involved in the regulation of milk genes. In this work we have been able to identify the splice variant NF1-C2 as an important member of
Eva M Johansson et al.
Oncogene, 22(38), 6061-6070 (2003-09-05)
The p53 tumor suppressor protein plays an important role in preventing cancer development by arresting or killing potential tumor cells. Downregulated p53 levels, or mutations within the p53 gene, leading to the loss of p53 activity, are found in many
Namrata Rastogi et al.
Leukemia, 37(2), 276-287 (2022-12-27)
Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds to DNA through CAATT-boxes and are involved in cellular differentiation and stem cell maintenance. Here we show NFIC protein is significantly overexpressed in 69% of acute
Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines.
Brun, M; Glubrecht, DD; Baksh, S; Godbout, R
The Journal of Biological Chemistry null
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