ABC835

Anti-SDHD Antibody

from rabbit, purified by affinity chromatography

• 別名: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, CybS, CII-4, QPs3, Succinate dehydrogenase complex subunit D, Succinate-ubiquinone oxidoreductase cytochrome b small subunit, Succinate-ubiquinone reductase membrane anchor s
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: mouse
• テクニック: immunocytochemistry: suitable; western blot: suitable
• UniProtアクセッション番号: O14521
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SDHD(6392)

詳細

詳細

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as CII-4 or QPs3 or Succinate dehydrogenase complex subunit D or Succinate-ubiquinone oxidoreductase cytochrome b small subunit or Succinate-ubiquinone reductase membrane anchor subunit, and encoded by the gene name SDHD or SD14, is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumorsuppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

免疫原

Epitope: center region

KLH-conjugated synthetic peptide corresponding to the center region of human Anti-SDHD.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

Detect SDHD using this Anti-SDHD Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 2.5 μg/mL from a representative lot detected Anti-SDHD in EL4 cells.

品質

Evaluated by Western Blotting in EL4 cell lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected Anti-SDHD in EL4 cell lysate.

ターゲットの説明

~16 kDa observed. Uncharacterized bands may be observed in some lysate(s).

物理的形状

Affinity

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable