ABC462

Anti-DNA polymerase subunit gamma-1 Antibody/POLG

1.0 mg/mL, from rabbit

• 別名: DNA polymerase subunit gamma-1, DNA polymerase subunit gamma-1, PolG-alpha
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• 濃度: 1.0 mg/mL
• テクニック: immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• NCBIアクセッション番号: NP_001119603
• UniProtアクセッション番号: P54098
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... POLG(5428)

詳細

詳細

POLG is a mitochondrial protein that plays a major role in mitochondrial DNA replication and only for mitochondrial DNA. POLG is the catalytic subunit of a multiple protein complex that makes up the holo-enzyme that is the mitochondrial specific DNA polymerase gamma. POLG makes the alpha subunit of the complex. A number of diseases are associated with mutations that affect the function of POLG and the mitochondria including Leigh syndrome, various neurodegeneration diseases such as Parkinson’s and Alzheimer′s, as well as various skeletal muscle and ophthalmoplegia disorders and even male infertility. The polymerase that POLG ultimately comprises is Polymerase gamma (Pol γ) and is the only DNA polymerase that is active in mitochondria and that can replicate mtDNA.

免疫原

KLH-conjugated linear peptide corresponding to human DNA polymerase subunit gamma-1/POLG near the N-terminus.

アプリケーション

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DNA polymerase subunit gamma-1/POLG in human cerebellum, human cerebral cortex, human tonsil and human thalamus tissue.
Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated DNA polymerase subunit gamma-1/POLG in 0.5 mg of HeLa cell lysate.

This Anti-DNA polymerase subunit gamma-1 Antibody/POLG is validated for use in Immunohistochemistry and Immunoprecipitation for the detection of DNA polymerase subunit gamma-1/POLG.

品質

Evaluated by Immunohistochemistry in human tonsil tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected DNA polymerase subunit gamma-1/POLG in human tonsil tissue.

ターゲットの説明

~140 kDa observed. Uncharacterized band(s) may appear in some lysates.

関連事項

Replaces: MABN1088

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable