AB5675-AF488

Anti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor^™ 488

from rabbit, ALEXA FLUOR^™ 488

• 別名: Metabotropic glutamate receptor 5, mGluR5, G protein-coupled receptor GRM5, G protein coupled receptor family C, group 1, member E
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: ALEXA FLUOR^™ 488
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: rat
• 化学種の反応性（ホモロジーによる予測）: bovine (based on 100% sequence homology), primate (based on 100% sequence homology), horse (based on 100% sequence homology), human (based on 100% sequence homology), mouse (based on 100% sequence homology), feline (based on 100% sequence homology)
• テクニック: immunocytochemistry: suitable; immunofluorescence: suitable
• NCBIアクセッション番号: NP_001137306
• UniProtアクセッション番号: Q3UVX5
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GRM5(2915)

詳細

詳細

Metabotropic glutamate receptor 5 or mGluR5 (UniProt P31424; also known as G protein-coupled receptor GRM5, G protein coupled receptor family C, group 1, member E) is encoded by the Grm5 (also known as Gprc1e, Mglur5) gene (Gene ID 24418) in rat species. The metabotropic glutamate receptors belong to a family of G protein-coupled receptors that have been divided into 3 groups based on their sequence homology, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 and mGluR5 constitute Group I metabotropic glutamate receptors. mGluR5 is found on postsynaptic terminals of neurons and microglia. mGluR5 signals via Gq/G11 coupling to activate phospholipase C, resulting in calcium mobilization and activation of protein kinase C (PKC). In addition, mGluR5 is also reported to mediate signaling involving Src-family protein tyrosine kinase in a G protein-independent manner.

特異性

Expected to react with all spliced isoforms of human, rat, and mouse mGluR5 reported by UniProt (P41594, P31424 and Q3UVX5, respectively).

免疫原

Epitope: C-terminal cyoplasmic domain.

Synthetic peptide corresponding to a sequence from the C-terminal cytoplasmic domain of rat mGluR5.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
神経伝達物質及び受容体

Anti-Metabotropic Glutamate Receptor 5 Antibody, Alexa Fluor^™ 488 is an antibody against Metabotropic Glutamate Receptor 5 for use in Immunocytochemistry, Immunofluorescence.

Immunocytochemistry Analysis: An 1:100 dilution from a representative lot detected Metabotropic Glutamate Receptor 5 in rat cortical neurons.
The unconjugated antibody (Cat. No. AB5675) is shown to be suitable also for Western blotting and immunohistochemistry applications.

品質

Evaluated by Immunofluorescence in rat brain tissue sections.

Immunofluorescence Analysis: An 1:100 dilution of this antibody detected Metabotropic Glutamate Receptor 5 in rat cerebellum and rat brain tissue sections.

ターゲットの説明

~150 kDa observed.

物理的形状

Affinity purified

Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

法的情報

ALEXA FLUOR is a trademark of Life Technologies

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable