AB3092

Anti-Orexin-1 Receptor Antibody

Chemicon^®, from rabbit

• 別名: OX1R, Hypocretin Receptor 1
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: rat, human, mouse
• メーカー／製品名: Chemicon^®
• テクニック: ELISA: suitable; western blot: suitable
• NCBIアクセッション番号: NM_001525.1
• UniProtアクセッション番号: O43613
• 輸送温度: dry ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... HCRTR1(3061)

詳細

詳細

Several peptides associated with feeding behavior have been reported recently. Orexins (Orexin-A and Orexin-B) are a family of hypothalamic neuropeptides selectively expressed in the hypothalamus (Sakurai et al. 1998). Orexin-A and Orexin-B are derived from the same precursor (Prepro-orexin) by proteolytic cleavage. Prepro-orexin is an 130 aa peptide with a putative 33 aa secretory sequence, a hydrophobic core followed by residues with small polar side chains. The expression was detected in brain and to a small extent in testis (Sakurai et al. 1998). These neuropeptides bind and activate two closely related Orexin receptors--G protein coupled receptors (GPCRs) OX1R and OX2R.

特異性

Recognizes Rat and Human Orexin-1.

免疫原

A 16 aa peptide near the N-terminus of rat OX1R and a 16 aa peptide near the C-terminus of human OX1R.

アプリケーション

Research Category
ニューロサイエンス

Research Sub Category
CNSによる代謝制御

サーカディアンリズム及び睡眠

This Anti-Orexin-1 Receptor Antibody is validated for use in ELISA, WB for the detection of Orexin-1 Receptor.

Western blot: 1-10 μg/mL using Chemiluminescence technique. Protein runs at 45-48 kDa.

ELISA: 1:10,000 -1:100,000 against 50-100 ng/wel immunogen peptide.

Optimal working dilutions must be determined by end user.

ターゲットの説明

45-48 kDa

物理的形状

ImmunoAffinity Purified

Affinity Purified immunoglobulin. Liquid in PBS with 0.1% BSA.

保管および安定性

Maintain for 6 months at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

アナリシスノート

Control
Hypothalamus

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable