8.52066-M

Fmoc-Thr(Trt)-OH

Novabiochem^®

• 別名: Fmoc-Thr(Trt)-OH, N-α-Fmoc-O-trityl-L-threonine
• 実験式（ヒル表記法）: C₃₈H₃₃NO₅
• CAS番号: 133180-01-5
• 分子量: 583.67
• MDL番号: MFCD00237034
• UNSPSCコード: 12352209
• NACRES: NA.22

特性

• 品質水準: 200
• アッセイ: ≥78.0% (acidimetric); ≥98% (TLC); ≥98.0% (HPLC)
• フォーム: powder
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• メーカー／製品名: Novabiochem^®
• mp: 70-85 °C
• アプリケーション: peptide synthesis
• 官能基: hydroxyl
• 保管温度: 15-25°C
• SMILES記法: N([C@@H]([C@H](OC(c6ccccc6)(c5ccccc5)c4ccccc4)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C38H33NO5/c1-26(44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29)35(36(40)41)39-37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34/h2-24,26,34-35H,25H2,1H3,(H,39,42)(H,40,41)/t26-,35+/m1/s1
• InChI Key: JARBLLDDSTVWSM-IJAHGLKVSA-N

詳細

詳細

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphothreonine containing peptides and peptides modified at the threonine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2].

The product number for this product was previously 04-12-1141.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

関連事項

Replaces: 04-12-1141

アナリシスノート

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 78.0 %
Water (K. F.): ≤ 1.5 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable