681640

Wee1 Inhibitor

The Wee1 Inhibitor, also referenced under CAS 622855-37-2, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Wee1 Inhibitor, 4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V
• 実験式（ヒル表記法）: C₂₀H₁₁ClN₂O₃
• CAS番号: 622855-37-2
• 分子量: 362.77
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• 有効性: 11 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: light orange
• 溶解性: DMSO: 10 mg/mL; ethanol: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)
• InChI Key: DPEXRCOBPACFOO-UHFFFAOYSA-N

詳細

詳細

A pyrrolocarbazole compound that acts as a poten, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 440 nM).

A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 440 nM).

生物化学的／生理学的作用

Cell permeable: no

Product competes with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable