676777

(±)-Verapamil, Hydrochloride

A papaverine derivative that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells.

• 別名: (±)-Verapamil, Hydrochloride, L-Type Calcium Channel Blocker V
• 実験式（ヒル表記法）: C₂₇H₃₈N₂O₄ · xHCl
• CAS番号: 152-11-4
• 分子量: 454.60 (free base basis)
• MDL番号: MFCD00055208
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥99% (perchloric acid titration)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: methanol: 50 mg/mL; water: 70 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
• InChI Key: DOQPXTMNIUCOSY-UHFFFAOYSA-N

詳細

詳細

A derivative of papaverine that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Inhibits the entry of Ca²⁺ through voltage-dependent Ca²⁺ channels in cell membranes. Blocks both activated and inactivated Ca²⁺ channels. An adrenergic antagonist. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.

A papaverine derivative that blocks Ca²⁺ channels (principally the L-type) in smooth and cardiac muscle cells. Vasodilator and antiarrhythmic agent. Known to reduce the renal clearance of digoxin. Induces apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Toxic (F)

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Lonsberry, B.B., et al. 1994. Pharmacology 49, 23.
Shchepotin, I.B., et al. 1994. Anticancer Res.14, 1027.
Janis, R., et al. 1987. Adv. Drug Res.16, 309.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06,GHS09
• シグナルワード: Danger
• 危険有害性情報: H301,H411
• 注意書き: P264 - P273 - P301 + P310 - P391 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral - Aquatic Chronic 2
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable