658548

AG 1478

InSolution, ≥98%, inhibitor EGF receptor tyrosine kinase

• 別名: InSolution AG 1478
• 実験式（ヒル表記法）: C₁₆H₁₄ClN₃O₂
• CAS番号: 175178-82-2
• 分子量: 315.75
• MDL番号: MFCD00270914
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: clearfaint tan
• 輸送温度: wet ice
• 保管温度: −20°C
• InChI: 1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
• InChI Key: GFNNBHLJANVSQV-UHFFFAOYSA-N

詳細

詳細

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC₅₀ >100 µM), the platelet-derived growth factor (PDGF) receptor (IC₅₀ >100 µM), and p210^Bcr-Abl (IC₅₀ >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Epidermal growth factor receptor kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 3 nM against of epidermal growth factor receptor kinase

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.

再構成

Following initial thaw, aliquot and freeze (-20°C).

その他情報

Levitski, A., and Gazit, A. 1995. Science267, 1782.
Fry, D.W., et al. 1994. Science265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem.225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

法的情報

Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)