579053

TAPI-1

≥97% (HPLC), liquid, MMP and TACE inhibitor, Calbiochem^®

• 別名: InSolution TAPI-1
• 実験式（ヒル表記法）: C₂₆H₃₇N₅O₅
• 分子量: 499.60
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: TAPI-1, InSolution, ≥97%, inhibits MMPs and TACE
• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• 形状: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

詳細

A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC₅₀ = 8.09 μM) and muscarinic receptor-stimulated (IC₅₀ = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC₅₀ = 920 nM).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
MMPs and TACE

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 8.09 µM, 3.61 µM in blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579051) in DMSO.

再構成

Following initial thaw, aliquot and freeze (-20°C).

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)