572630

SU-5402

≥95% (HPLC), lyophilized solid, FGFR1 inhibitor, Calbiochem

• 別名: SU5402, 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
• 実験式（ヒル表記法）: C₁₇H₁₆N₂O₃
• CAS番号: 215543-92-3
• 分子量: 296.32
• MDL番号: MFCD08235144
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: SU5402, SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP).
• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 溶解性: DMSO: 25 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [nH]1c(c(c(c1)C)CCC(=O)O)\C=C2\c3c(cccc3)NC\2=O
• InChI: 1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
• InChI Key: JNDVEAXZWJIOKB-JYRVWZFOSA-N

詳細

詳細

A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC₅₀ = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC₅₀ = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Fibroblast growth factor receptor 1 (FGFR1)

Product competes with ATP.

Reversible: yes

Target IC₅₀: 10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Mohammadi, M., et al. 1997. Science 276, 955.

法的情報

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable