567726

D-erythro-Sphingosine, Free Base, High Purity

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

• 別名: D-erythro-Sphingosine, Free Base, High Purity, Cerebroside, trans-D- erythro-2-Amino-4-octadecene-1,3-diol, Ceramide, Cerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
• 実験式（ヒル表記法）: C₁₈H₃₇NO₂
• CAS番号: 123-78-4
• 分子量: 299.49
• MDL番号: MFCD00036751
• UNSPSCコード: 12352211
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: chloroform: 1 mg/mL; methanol: 1 mg/mL; DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
• InChI Key: WWUZIQQURGPMPG-KRWOKUGFSA-N

詳細

詳細

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC₅₀ = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca²⁺. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
PKC

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.8 µM against PKC

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 危険有害性情報: H413
• 注意書き: P273 - P501
• 危険有害性の分類: Aquatic Chronic 4
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable