310500

D-erythro-Sphingosine, N,N-Dimethyl-

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity.

• 別名: D-erythro-Sphingosine, N,N-Dimethyl-, DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
• 実験式（ヒル表記法）: C₂₀H₄₁NO₂
• CAS番号: 119567-63-4
• 分子量: 327.55
• UNSPSCコード: 12352211
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• 形状: oil (Clear); waxy solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 溶解性: DMSO: 5 mg/mL; ethanol: soluble; methanol: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
• InChI Key: YRXOQXUDKDCXME-YIVRLKKSSA-N

詳細

詳細

A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 12 µM against PKC

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

その他情報

Cuvillier, O., et al. 1996. Nature381, 800.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable