567565

Sodium Stibogluconate

A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex.

• 別名: Sodium Stibogluconate, SSG, Antimony Sodium Gluconate, NaSb^v, PTP Inhibitor XXIV, SHP1 Inhibitor IV
• 実験式（ヒル表記法）: C₁₂H₁₇O₁₇Sb₂ · 3Na · 9H₂O
• CAS番号: 16037-91-5
• 分子量: 907.88
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥90% dry basis (≥30% Sb content, titration)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated; protect from light
• 色: white
• 溶解性: water: 1 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/2C6H10O7.3Na.9H2O.3O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-8,10H,1H2,(H,12,13);;;;9*1H2;;;;;/q2*-2;3*+1;;;;;;;;;;;;;2*+2/p-2/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1
• InChI Key: CUEDNFKBTFCOSV-UZVLBLASSA-L

詳細

詳細

A pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (EC_max = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (EC_max = 55 µM). Exhibits anti-leishmanial effects.

A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
PTPase activity, including Src homology PTPase-1 (SHP-1)

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: ~11 µM causing 99% inhibition of protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1)

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

調製ノート

Heating to 75°C with constant stirring or constant stirring overnight at room temperature may be required for complete solubilization.

再構成

Unstable in solution; reconstitute just prior to use.

その他情報

Wortmann, G., et al. 2002. Clin. Infect. Dis.35, 261.
Pathak, M.K. and Yi, T. 2001. J. Immunol.167, 3391.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H302 + H332,H411
• 注意書き: P261 - P264 - P271 - P273 - P301 + P312 - P304 + P340 + P312
• 危険有害性の分類: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable