565755

γ-Secretase Inhibitor II

The γ-Secretase Inhibitor II controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: γ-Secretase Inhibitor II, MW167
• 実験式（ヒル表記法）: C₃₃H₅₇F₂N₅O₉
• 分子量: 705.83
• UNSPSCコード: 12352200
• NACRES: NA.54

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 10 mM
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC₅₀ = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC₅₀ of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC₅₀ = 100 µM in a purified enzyme assay).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 13 µM against γ-secretase

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Wolfe, M.S., et al. 1999. Biochemistry38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 13170.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable