565740

α-Amyloid Precursor Protein Modulator

≥95% (HPLC), solid, PKC activator, Calbiochem^®

• 別名: α-Amyloid Precursor Protein Modulator, (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
• 実験式（ヒル表記法）: C₂₇H₃₀F₃N₃O₃
• CAS番号: 497259-23-1
• 分子量: 501.54
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• product name: α-Amyloid Precursor Protein Modulator, A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848.
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange
• 溶解性: methanol: 1 mg/mL; DMSO: 50 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C
• InChI: 1S/C27H30F3N3O3/c1-17(2)25-26(36)32-22(16-34)15-19-14-21(12-13-23(19)33(25)3)31-24(35)7-5-4-6-18-8-10-20(11-9-18)27(28,29)30/h4-14,17,22,25,34H,15-16H2,1-3H3,(H,31,35)(H,32,36)/b6-4+,7-5+/t22-,25-/m0/s1
• InChI Key: WOLVEMPZUIFSII-IHHOKICGSA-N

詳細

詳細

A cell-permeable PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.

A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: no

Target K_i: 11.9 nM for activating PKCα

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Kozikowski, A.P., et al. 2003. J. Med. Chem.46, 364.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable