557403

RNA Polymerase III Inhibitor

RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

• 別名: RNA Polymerase III Inhibitor, ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
• 実験式（ヒル表記法）: C₁₉H₁₅Cl₂N₃O₂S₂
• CAS番号: 577784-91-9
• 分子量: 452.38
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 15 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C19H15Cl2N3O2S2/c1-11-13-9-12(20)7-8-16(13)27-19(11)15-10-18(24(2)22-15)23-28(25,26)17-6-4-3-5-14(17)21/h3-10,23H,1-2H3
• InChI Key: BVBDTTLISMIOJY-UHFFFAOYSA-N

詳細

詳細

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).

A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC₅₀ = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
activity against RNA Polymerase III

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 27 and 32 µM for Human and S. cerevisiae RNA Pol III

包装

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

調製ノート

Slight warming may be necessary to achieve complete solubilization.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Wu, L., et al. 2003. Euk. Cell2, 256.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable